Publications Wurst

2023

• González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C (2023)
  Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
  Cell Metab. 2023 Mar 7;35(3):438-455.e7. doi: 10.1016/j.cmet.2023.02.004. PMID: 36889283.
• Stroo E, Janssen L, Sin O, Hogewerf W, Koster M, Harkema L, Youssef SA, Beschorner N, Wolters AH, Bakker B, Becker L, Garrett L, Marschall S, Hoelter SM, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Thathiah A, Foijer F, van de Sluis B, van Deursen J, Jucker M, de Bruin A, Nollen EA (2023)
  Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
  Life Sci Alliance. 2023 May 2;6(7):e202201730. doi: 0.26508/lsa.202201730. PMID: 37130781; PMCID: PMC10155860.
• Wefers B, Wurst W Kühn R (2023)
  Gene Editing in Mouse Zygotes Using the CRISPR/Cas9 System.
  Methods Mol Biol. 2023;2631:207-230. doi: 10.1007/978-1-0716-2990-1_8. PMID: 36995669.

2022

• Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ (2022)
  PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing.
  Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. PMID: 35618940.
• Giehrl-Schwab J, Giesert F, Rauser B, Lao CL, Hembach S, Lefort S, Ibarra IL, Koupourtidou C, Luecken MD, Truong DJ, Fischer-Sternjak J, Masserdotti G, Prakash N, Ninkovic J, Giehrl-Schwab J, Giesert F, Rauser B, Lao CL, Hembach S, Lefort S, Ibarra IL, Koupourtidou C, Luecken MD, Truong DJ, Fischer-Sternjak J, Masserdotti G, Prakash N, Ninkovic J, Hölter SM, Vogt Weisenhorn DM, Theis FJ, Götz M, Wurst W (2022)
  Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
  EMBO Mol Med. 2022 Apr 4:e14797. doi: 10.15252/emmm.202114797. Epub ahead of print. PMID: 35373464.
• Klein-Rodewald T, Micklich K, Sanz-Moreno A, Tost M, Calzada-Wack J, Adler T, Klaften M, Sabrautzki S, Aigner B, Kraiger M, Gailus-Durner V, Fuchs H; German Mouse Clinic Consortium [i.a. Wurst W], Gründer A, Pahl H, Wolf E, Hrabe de Angelis M, Rathkolb B (2022)
  New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance.
  Sci Rep. 2022 Nov 17;12(1):19793. doi: 10.1038/s41598-022-23218-5. PMID: 36396684; PMCID: PMC9671887.
• Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD (2022)
  Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
  Mol Metab. 2022 Oct 18:101616. doi: 10.1016/j.molmet.2022.101616. Epub ahead of print. PMID: 36270613.
• Sanchez-Gonzalez R, Koupourtidou C, Lepko T, Zambusi A, Novoselc KT, Durovic T, Aschenbroich S, Schwarz V, Breunig CT, Straka H, Huttner HB, Irmler M, Beckers J, Wurst W, Zwergal A, Schauer T, Straub T, Czopka T, Trümbach D, Götz M, Stricker SH, Ninkovic J (2022)
  Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain.
  Cells. 2022 Feb 2;11(3):520. doi: 10.3390/cells11030520. PMID: 35159329; PMCID: PMC8834209.
• Schmidt S, Vogt Weisenhorn DM, Wurst W (2022)
  Chapter 5 - "Parkinson's disease - A role of non-enzymatic posttranslational modifications in disease onset and progression?".
  Mol Aspects Med. 2022 Apr 1:101096. doi: 10.1016/j.mam.2022.101096. Epub ahead of print. PMID: 35370007.
• Schmidt S, Luecken MD, Trümbach D, Hembach S, Niedermeier KM, Wenck N, Pflügler K, Stautner C, Böttcher A, Lickert H, Ramirez-Suastegui C, Ahmad R, Ziller MJ, Fitzgerald JC, Ruf V, van de Berg WDJ, Jonker AJ, Gasser T, Winner B, Winkler J, Vogt Weisenhorn DM, Giesert F, Theis FJ, Wurst W (2022)
  Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
  Nat Commun. 2022 Aug 16;13(1):4819. doi: 10.1038/s41467-022-32229-9. PMID: 35974013; PMCID: PMC9380673.
• Xie K, Fuchs H, Scifo E, Liu D, Aziz A, Aguilar-Pimentel JA, Amarie OV, Becker L, da Silva-Buttkus P, Calzada-Wack J, Cho YL, Deng Y, Edwards AC, Garrett L, Georgopoulou C, Gerlini R, Hölter SM, Klein-Rodewald T, Kramer M, Leuchtenberger S, Lountzi D, Mayer-Kuckuk P, Nover LL, Oestereicher MA, Overkott C, Pearson BL, Rathkolb B, Rozman J, Russ J, Schaaf K, Spielmann N, Sanz-Moreno A, Stoeger C, Treise I, Bano D, Busch DH, Graw J, Klingenspor M, Klopstock T, Mock BA, Salomoni P, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Gailus-Durner V, Breteler MMB, Hrabě de Angelis M, Ehninger D (2022)
  Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
  Nat Commun. 2022 Nov 11;13(1):6830. doi: 10.1038/s41467-022-34515-y. PMID: 36369285; PMCID: PMC9652467.

2021

• Biagosch CA, Vidali S, Faerberboeck M, Hensler SV, Becker L, Amarie OV, Aguilar-Pimentel A, Garrett L, Klein-Rodewald T, Rathkolb B, Zanuttigh E, Calzada-Wack J, da Silva-Buttkus P, Rozman J, Treise I, Fuchs H, Gailus-Durner V, de Angelis MH, Janik D, Wurst W. Mayr JA, Klopstock T. eitinger T, Prokisch H, Iuso A (2021)
  A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse.
  Mamm Genome. 2021 May 27. doi: 10.1007/s00335-021-09875-3. Epub ahead of print. PMID: 34043061.
• Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W (2021)
  DGK and DZHK position paper on genome editing: basic science applications and future perspective
  Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3. PMID: 33449167.
• Findeiss E, Schwarz SC, Evsyukov V, Rösler TW, Höllerhage M, Chakroun T, Nykänen NP, Shen Y, Wurst W. Kohl M, Tost J, Höglinger GU (2021)
  Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes.
  Front Cell Dev Biol. 2021 Mar 4;9:561086. doi: 10.3389/fcell.2021.561086. PMID: 33748099; PMCID: PMC7969723.
• Garrett L, Da Silva-Buttkus P, Rathkolb B, Gerlini R, Becker L, Sanz-Moreno A, Seisenberger C, Zimprich A, Aguilar-Pimentel A, Amarie OV, Cho YL, Kraiger M, Spielmann N, Calzada-Wack J, Marschall S, Busch D, Schmitt-Weber C, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, Hölter SM, de Angelis MH (2021)
  Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
  Dis Model Mech. 2021 Dec 29:dmm.049205. doi: 10.1242/dmm.049205. Epub ahead of print. PMID: 34964047.
• Hansen J, von Melchner H, Wurst W (2021)
  Mutant non-coding RNA resource in mouse embryonic stem cells.
  Dis Model Mech. 2021 Feb 5;14(2):dmm047803. doi: 10.1242/dmm.047803. PMID: 33729986; PMCID: PMC7875499.
• Hsia HE, Tüshaus J, Feng X, Hofmann LI, Wefers B, Marciano DK, Wurst W, Lichtenthaler S (2021)
  Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons
  FASEB J. 2021 Sep;35(9):e21813. doi: 10.1096/fj.202100475R. PMID: 34390512.
• Kupatt C, Windisch A, Moretti A, Wolf E, Wurst W, Walter MC (2021)
  Genome editing for Duchenne muscular dystrophy: a glimpse of the future?
  Gene Ther. 2021 Feb 2. doi: 10.1038/s41434-021-00222-4. Epub ahead of print. PMID: 33531685.
• O'Neill TJ, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, Graß C, Schmidt H, Kriegsmann K, Tofaute MJ, Demski K, Poth T, Rosenbaum M, Schnalzger T, Ruland J, Göttlicher M, Kriegsmann M, Naumann R, Heissmeyer V, Plettenburg O, Wurst W, Krappmann D (2021)
  TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
  Sci Immunol. 2021 Nov 12;6(65):eabh2095. doi: 10.1126/sciimmunol.abh2095. Epub 2021 Nov 12. PMID: 34767456.
• Schänzer A, Achleitner M, Trümbach D, Hubert L, Munnich A, Ahlemeyer B, AlAbdulrahim MM, Greif PA, Vosberg S, Hummer B, Feichtinger RG, Mayr JA, Wortmann SB, Aichner H, Rudnik-Schöneborn S, Ruiz A, Gabau E, Sánchez JP, Ellard S, Homfray T, Stals KL, Wurst W, Neubauer BA, Acker T, Bohlander SK, Asensio C, Besmond C, Alkuraya FS, AlSayed MD, Hahn A, Weber A (2021)
  Mutations in HID1 cause syndromic infantile encephalopathy and hypopituitarism.
  Ann Neurol. 2021 May 17. doi: 10.1002/ana.26127. Epub ahead of print. PMID: 33999436.
• Weisheit I, Kroeger JA, Malik R, Wefers B, Lichtner P, Wurst W, Dichgans M, Paquet D (2021)
  Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
  Nat Protoc. 2021 Feb 17. doi: 10.1038/s41596-020-00481-2. Epub ahead of print. PMID: 33597771.

2020

• Baumann P, Schriever SC, Kullmann S, Zimprich A, Peter A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Wurst W, Tschöp MH, Heni M, Hölter SM, Pfluger PT (2020)
  Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
  Brain Behav. 2020 Nov 1:e01928. doi: 10.1002/brb3.1928. Epub ahead of print. PMID: 33131190.
• Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Vogt Weisenhorn DM, Wurst W, Baralle M, Krainc D, Gasser T, Wissinger B, Krüger R (2020)
  A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.
  Sci Transl Med. 2020;12(560):eaau3960. doi:10.1126/scitranslmed.aau3960
• Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D; Genomics England Research Consortium; International Mouse Phenotyping Consortium (2020)
  Human and mouse essentiality screens as a resource for disease gene discovery.
  Nat Commun. 2020 Jan 31;11(1):655. doi: 10.1038/s41467-020-14284-2.
• Chakroun T, Evsyukov V, Nykänen NP, Höllerhage M, Schmidt A, Kamp F, Ruf VC, Wurst W, Rösler TW, Höglinger GU (2020)
  Alpha-synuclein fragments trigger distinct aggregation pathways.
  Cell Death Dis. 2020 Feb 3;11(2):84. doi: 10.1038/s41419-020-2285-7.
• Garrett L, Chang YJ, Niedermeier KM, Heermann T, Enard W, Fuchs H, Gailus-Durner V, Angelis MH, Huttner WB, Wurst W, Hölter SM (2020)
  A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons.
  Transl Psychiatry. 2020 Feb 13;10(1):66. doi: 10.1038/s41398-020-0686-0.
• Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A; Mouse Phenome Database Team, Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M (2020)
  A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
  Mamm Genome. 2020 Feb 14. doi: 10.1007/s00335-020-09827-3. [Epub ahead of print]
• LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, Edbauer D (2020)
  Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
  Acta Neuropathol. 2020;10.1007/s00401-020-02176-0. doi:10.1007/s00401-020-02176-0 [published online ahead of print, 2020 Jun 19].
• Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM (2020)
  The Deep Genome Project.
  Genome Biol. 2020 Feb 3;21(1):18. doi: 10.1186/s13059-020-1931-9.
• Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020)
  The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
  Cell Rep. 2020 Mar 10;30(10):3506-3519.e6. doi: 10.1016/j.celrep.2020.02.060.
• Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C (2020)
  Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
  Nat Med. 2020 Jan 27. doi: 10.1038/s41591-019-0738-2. [Epub ahead of print]
• Nouri P, Götz S, Rauser B, Irmler M, Peng C, Trümbach D, Kempny C, Lechermeier CG, Bryniok A, Dlugos A, Euchner E, Beckers J, Brodski C, Klümper C, Wurst W, Prakash N (2020)
  Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
  Front Cell Dev Biol. 2020 Oct 26;8:587778. doi: 10.3389/fcell.2020.587778. PMID: 33195246; PMCID: PMC7649324.
• Russo GL, Sonsalla G, Natarajan P, Breunig CT, Bulli G, Merl-Pham J, Schmitt S, Giehrl-Schwab J, Giesert F, Jastroch M, Zischka H, Wurst W, Stricker SH, Hauck SM, Masserdotti G, Götz M (2020)
  CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion.
  Cell Stem Cell. 2020 Nov 9:S1934-5909(20)30509-9. doi: 10.1016/j.stem.2020.10.015. Epub ahead of print. PMID: 33202244.
• Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, Martinez S, Wu M, Häring HU, Hrabe de Angelis M, Beckers J, Müller TD, Stemmer K, Wurst W, Rozman J, Nogueiras R, De Angelis M, Molkentin JD, Krahmer N, Yi CX, Schmidt MV, Luquet S, Heni M, Tschoep MH, Pfluger PT (2020)
  Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
  J Clin Invest. 2020;136363. doi:10.1172/JCI136363 [published online ahead of print, 2020 Aug 11]
• Swan AL, Schütt C, Rozman J, Del Mar Muñiz Moreno M, Brandmaier S, Simon M, Leuchtenberger S, Griffiths M, Brommage R, Keskivali-Bond P, Grallert H, Werner T, Teperino R, Becker L, Miller G, Moshiri A, Seavitt JR, Cissell DD, Meehan TF, Acar EF, Lelliott CJ, Flenniken AM, Champy MF, Sorg T, Ayadi A, Braun RE, Cater H, Dickinson ME, Flicek P, Gallegos J, Ghirardello EJ, Heaney JD, Jacquot S, Lally C, Logan JG, Teboul L, Mason J, Spielmann N, McKerlie C, Murray SA, Nutter LMJ, Odfalk KF, Parkinson H, Prochazka J, Reynolds CL, Selloum M, Spoutil F, Svenson KL, Vales TS, Wells SE, White JK, Sedlacek R, Wurst W, Lloyd KKC, Croucher PI, Fuchs H, Williams GR, Bassett D, Gailus-Durner V, Herault Y, Mallon AM, Brown SDM, Mayer-Kuckuk P, Hrabe de Angelis M; IMPC Consortium (2020)
  Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
  PLoS Genet. 2020 Dec 28;16(12):e1009190. doi: 10.1371/journal.pgen.1009190. Epub ahead of print. PMID: 33370286.
• Takalo M, Wittrahm R, Wefers B, Parhizkar S, Jokivarsi K, Kuulasmaa T, Mäkinen P, Martiskainen H, Wurst W, Xiang X, Marttinen M, Poutiainen P, Haapasalo A, Hiltunen M, Haass C (2020)
  The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
  Mol Neurodegener. 2020 Sep 11;15(1):52. doi: 10.1186/s13024-020-00402-7. PMID: 32917267.
• Ung MC, Garrett L, Dalke C, Leitner V, Dragosa D, Hladik D, Neff F, Wagner F, Zitzelsberger H, Miller G, Hrabě de Angelis M, Rößler U, Vogt Weisenhorn D, Wurst W, Graw J, Hölter SM (2020)
  Dose-dependent long-term effects of a single radiation event on behaviour and glial cells.
  Int J Radiat Biol. 2020 Dec 2:1-42. doi: 10.1080/09553002.2021.1857455. Epub ahead of print. PMID: 33264576.
• Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M (2020)
  Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
  Nat Struct Mol Biol. 2020 Feb;27(2):210-220. doi: 10.1038/s41594-019-0370-3. Epub 2020 Feb 3.
• Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A (2020)
  Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
  EMBO Rep. 2020 Sep 14:e50241. doi: 10.15252/embr.202050241. Epub ahead of print. PMID: 32929860.

2019

• Baumann P, Schriever SC, Kullmann S, Zimprich A, Feuchtinger A, Amarie O, Peter A, Walch A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Wurst W, Tschöp MH, Heni M, Hölter SM, Pfluger PT (2019)
  Dusp8 affects hippocampal size and behavior in mice and humans.
  Sci Rep. 2019 Dec 20;9(1):19483. doi: 10.1038/s41598-019-55527-7.
• Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L, Hölter SM; German Mouse Clinic Consortium [i.a. Wurst W ], Hrabě de Angelis M, Deutsch U, Engelhardt B (2019)
  Claudin-12 is not required for blood-brain barrier tight junction function.
  Fluids Barriers CNS. 2019 Sep 12;16(1):30. doi: 10.1186/s12987-019-0150-9.
• Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019)
  Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
  Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
• Funk N, Munz M, Ott T, Brockmann K, Wenninger-Weinzierl A, Kühn R, Vogt-Weisenhorn D, Giesert F, Wurst W, Gasser T, Biskup S (2019)
  The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulinstimulated translocation of GLUT4
  Sci Rep. 2019 Mar 14;9(1):4515. doi: 10.1038/s41598-019-40808-y.
• Höllerhage M, Fussi N, Rösler TW, Wurst W, Behrends C, Höglinger GU (2019)
  Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.
  Neuropharmacology. 2019 Feb 4;149:13-26. doi: 10.1016/j.neuropharm.2019.01.023. [Epub ahead of print]
• Lucienne M, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, da Silva-Buttkus P, Garrett L, Hölter SM, Mayer-Kuckuk P, Rathkolb B, Rozman J, Spielmann N, Treise I, Busch DH, Klopstock T, Schmidt-Weber C, Wolf E, Wurst W, Forny M, Mathis D, Fingerhut R, Froese DS, Gailus-Durner V, Fuchs H, de Angelis MH, Baumgartner MR (2019)
  In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.
  Biochim Biophys Acta Mol Basis Dis. 2019 Nov 23:165622. doi: 10.1016/j.bbadis.2019.165622. [Epub ahead of print]
• Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF (2019)
  Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
  FASEB J. 2019 Dec 27. doi: 10.1096/fj.201902347R. [Epub ahead of print]
• Segal J, Mülleder M, Krüger A, Adler T, Scholze-Wittler M, Becker L, Calzada-Wack J, Garrett L, Hölter SM, Rathkolb B, Rozman J, Racz I, Fischer R, Busch DH, Neff F, Klingenspor M, Klopstock T, Grüning NM, Michel S, Lukaszewska-McGreal B, Voigt I, Hartmann L, Timmermann B, Lehrach H, Wolf E, Wurst W, Gailus-Durner V, Fuchs H, de Angelis MH, Schrewe H, Yuneva M, Ralser M (2019)
  Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency.
  J Inherit Metab Dis. 2019 May 20. doi: 10.1002/jimd.12105. [Epub ahead of print]
• van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF (2019)
  A protein quality control pathway regulated by linear ubiquitination.
  EMBO J. 2019 Mar 18. pii: e100730. doi: 10.15252/embj.2018100730. [Epub ahead of print]
• Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Hrabě de Angelis M, Graw J (2019)
  Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
  Exp Eye Res. 2019 Apr 13. pii: S0014-4835(18)30702-4. doi: 10.1016/j.exer.2019.03.024. [Epub ahead of print]
• von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W Feederle R Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E (2019)
  Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
  J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762. [Epub ahead of print]

2018

• André V, Gau C, Scheideler A, Aguilar-Pimentel JA, Amarie OV, Becker L, Garrett L, Hans W, Hölter SM, Janik D, Moreth K, Neff F, Östereicher M, Racz I, Rathkolb B, Rozman J, Bekeredjian R, Graw J, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Wolf E, Wurst W, Gailus-Durner V, Brielmeier M, Fuchs H, Hrabé de Angelis M (2018)
  Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
  PLoS Biol. 2018 Apr 16;16(4):e2005019. doi: 10.1371/journal.pbio.2005019. [Epub ahead of print]
• Blume J, Ziętara N, Witzlau K, Liu Y, Sanchez OO, Puchałka J, Winter SJ, Kunze-Schumacher H, Saran N, Düber S, Roy B, Weiss S, Klein C, Wurst W, Łyszkiewicz M, Krueger A (2018)
  miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.
  Eur J Immunol. 2018 Oct 3. doi: 10.1002/eji.201847660. [Epub ahead of print]
• Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Trümbach D, Baumgart EV, Neuner AM, Beckers J, Wurst W, Stricker SH, Ninkovic J (2018)
  The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis
  Cell Rep. 2018 Dec 18;25(12):3241-3251.e5. doi: 10.1016/j.celrep.2018.11.055.
• Fussi N, Höllerhage M, Chakroun T, Nykänen NP, Rösler TW, Koeglsperger T, Wurst W, Behrends C, Höglinger GU (2018)
  Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.
  Cell Death Dis. 2018 Jul 9;9(7):757. doi: 10.1038/s41419-018-0816-2.
• Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, von Bohlen Und Halbach V, Rath M, Delatycki M, Bert B, Fink H, Blümlein K, Ralser M, Van Dijck A, Kooy F, Stark Z, Müller S, Scherthan H, Gecz J, Wurst W, Wolf E, Zimmer A, Klingenspor M, Graw J, Klopstock T, Busch D, Adamski J, Fuchs H, Gailus-Durner V, de Angelis MH, von Bohlen Und Halbach O, Ropers HH, Kuss AW (2018)
  A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.
  Biochim Biophys Acta Mol Basis Dis. 2018 Dec 14. pii: S0925-4439(18)30497-6. doi: 10.1016/j.bbadis.2018.12.011. [Epub ahead of print]
• Nikolakopoulou P, Chatzigeorgiou A, Kourtzelis I, Toutouna L, Masjkur J, Arps-Forker C, Poser SW, Rozman J, Rathkolb B, Aguilar-Pimentel JA; German Mouse Clinic Consortium [i.a. Wurst W ], Wolf E, Klingenspor M, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Tsata V, Monasor LS, Troullinaki M, Witt A, Anastasiou V, Chrousos G, Yi CX, García-Cáceres C, Tschöp MH, Bornstein SR, Androutsellis-Theotokis A (2018)
  Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.
  Sci Rep. 2018 Jul 27;8(1):11335. doi: 10.1038/s41598-018-29434-2.
• Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M (2018)
  Identification of genetic elements in metabolism by high-throughput mouse phenotyping
  Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2. [Epub ahead of print]
• Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC (2018)
  FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
  Neuron. 2018 Sep 19;99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017. Epub 2018 Sep 6.
• Weber A, Schwarz SC, Tost J, Trümbach D, Winter P, Busato F, Tacik P, Windhorst AC, Fagny M, Arzberger T, McLean C, van Swieten JC, Schwarz J, Vogt Weisenhorn D, Wurst W, Adhikary T, Dickson DW, Höglinger GU, Müller U (2018)
  Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.
  Nat Commun. 2018 Jul 26;9(1):2929. doi: 10.1038/s41467-018-05325-y.
• Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C (2018)
  The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
  Mol Neurodegener. 2018 Sep 6;13(1):49. doi: 10.1186/s13024-018-0280-6.

2017

• Danner E, Bashir S, Yumlu S, Wurst W, Wefers B, Kühn R (2017)
  Control of gene editing by manipulation of DNA repair mechanisms
  Mamm Genome. 2017 Apr 3. doi: 10.1007/s00335-017-9688-5. [Epub ahead of print]
• Egaña I, Kaito H, Nitzsche A, Becker L, Ballester-Lopez C, Niaudet C, Petkova M, Liu W, Vanlandewijck M, Vernaleken A, Klopstock T, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rask-Andersen H, Johansson HJ, Lehtiö J, He L, Yildirim AÖ, Hellström M; German Mouse Clinic Consortium (i.a. Wurst W) (2017)
  Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
  Sci Rep. 2017 Nov 13;7(1):15453. doi: 10.1038/s41598-017-14894-9.
• Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stoeger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M (2017)
  Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic
  Behav Brain Res. 2017 Sep 28. pii: S0166-4328(17)30931-2. doi: 10.1016/j.bbr.2017.09.048. [Epub ahead of print]
• Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM (2017)
  Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice
  Mol Neurobiol. 2017 Jul 10. doi: 10.1007/s12035-017-0659-3. [Epub ahead of print]
• Giesert F, Glasl L, Zimprich A, Ernst L, Piccoli G, Stautner C, Zerle J, Hölter SM, Vogt Weisenhorn DM, Wurst W (2017)
  The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse
  Neurobiol Dis. 2017 May 31;105:179-193. doi: 10.1016/j.nbd.2017.05.013. [Epub ahead of print]
• Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL; International Mouse Phenotyping Consortium (i.a. Wurst W), Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK (2017)
  Prevalence of sexual dimorphism in mammalian phenotypic traits
  Nat Commun. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475.
• Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C (2017)
  The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism
  EMBO J. 2017 May 30. pii: e201796516. doi: 10.15252/embj.201796516. [Epub ahead of print]
• Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C (2017)
  TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
  EMBO Rep. 2017 May 8. pii: e201743922. doi: 10.15252/embr.201743922. [Epub ahead of print]
• Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM (2017)
  Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality.
  J Neurosci. 2017 Oct 27. pii: 3487-16. doi: 10.1523/JNEUROSCI.3487-16.2017. [Epub ahead of print]
• Ryan DP, Henzel KS, Pearson BL, Siwek ME, Papazoglou A, Guo L, Paesler K, Yu M, Müller R, Xie K, Schröder S, Becker L, Garrett L, Hölter SM, Neff F, Rácz I, Rathkolb B, Rozman J, Ehninger G, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Sidiropoulou K, Weiergräber M, Zhou Y, Ehninger D (2017)
  A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
  Mol Psychiatry. 2017 Apr 4. doi: 10.1038/mp.2017.53. [Epub ahead of print]
• Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I; German Mouse Clinic Consortium, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, Torres M, Fuchs H, de Angelis MH, Wurst W, Hölter SM, Winkelmann J (2017)
  Meis1 effects on motor phenotypes and the sensorimotor system in mice
  Dis Model Mech. 2017 Jun 23. pii: dmm.030080. doi: 10.1242/dmm.030080. [Epub ahead of print] .
• Schludi MH, Becker L, Garrett L, Gendron TF, Zhou Q, Schreiber F, Popper B, Dimou L, Strom TM, Winkelmann J, von Thaden A, Rentzsch K, May S, Michaelsen M, Schwenk BM, Tan J, Schoser B, Dieterich M, Petrucelli L, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Klopstock T, Arzberger T, Edbauer D (2017)
  Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss
  Acta Neuropathol. 2017 Apr 13. doi: 10.1007/s00401-017-1711-0. [Epub ahead of print]
• Schriever SC, Zimprich A, Pfuhlmann K, Baumann P, Giesert F, Klaus V, Kabra DG, Hafen U, Romanov A, Tschöp MH, Wurst W, Conrad M, Hölter SM, Vogt Weisenhorn D, Pfluger PT (2017)
  Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency
  Neuroscience. 2017 Jun 13. pii: S0306-4522(17)30384-6. doi: 10.1016/j.neuroscience.2017.05.050. [Epub ahead of print]
• Trümbach D, Pfeiffer S, Poppe M, Scherb H, Doll S, Wurst W, Schick JA (2017)
  ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis.
  BMC Genomics. 2017 Nov 25;18(1):905. doi: 10.1186/s12864-017-4285-2.
• Vartholomaiou E, Madon-Simon M, Hagmann S, Mühlebach G, Wurst W, Floss T, Picard D (2017)
  Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model
  Oncotarget. 2017 Mar 14;8(11):17428-17442. doi: 10.18632/oncotarget.15659.
• Wefers B, Bashir S, Rossius J, Wurst W, Kühn R (2017)
  Gene editing in mouse zygotes using the CRISPR/Cas9 system
  Methods. 2017 Mar 2. pii: S1046-2023(16)30469-8. doi: 10.1016/j.ymeth.2017.02.008. [Epub ahead of print]
• Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D (2017)
  Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
  Nat Commun. 2017 Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3.
• Zimprich A, Östereicher MA, Becker L, Dirscherl P, Ernst L, Fuchs H, Gailus-Durner V, Garrett L, Giesert F, Glasl L, Hummel A, Rozman J, de Angelis MH, Vogt-Weisenhorn D, Wurst W, Hölter SM (2017)
  Analysis of Locomotor Behavior in the German Mouse Clinic
  J Neurosci Methods. 2017 May 5. pii: S0165-0270(17)30124-3. doi: 10.1016/j.jneumeth.2017.05.005. [Epub ahead of print]

2016

• Deng T, Postnikov Y, Zhang S, Garrett L, Becker L, Rácz I, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Bustin M (2016)
  Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation
  Nucleic Acids Res. 2016 Dec 6. pii: gkw1222. [Epub ahead of print]
• Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium [i.a. Wurst W ], Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N (2016)
  Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
  Nat Commun. 2016 Apr 28;7:11317. doi: 15.13155/ncomms11317.
• Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabě de Angelis M (2016)
  The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
  G3 (Bethesda). 2016 Nov 4. pii: g3.116.033670. doi: 10.1534/g3.116.033670. [Epub ahead of print]
• Klafke R, Prem Anand AA, Wurst W, Prakash N, Wizenmann A (2016)
  Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development
  Development. 2016 Jan 11. pii: dev.126748. [Epub ahead of print]
• Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, D'Herouel AF, Dong X, Weindl D, Stautner C, Nonnenmacher Y, Michelucci A, Popp O, Giesert F, Schildknecht S, Krämer L, Schneider JG, Woitalla D, Wurst W, Skupin A, Weisenhorn DM, Krüger R, Leist M, Hiller K (2016)
  Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
  Neurobiol Dis. 2016 Jan 30. pii: S0969-9961(16)30019-5. doi: 10.1016/j.nbd.2016.01.019. [Epub ahead of print]
• Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM (2016)
  Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice
  Purinergic Signal. 2016 Nov 17. [Epub ahead of print]
• Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G (2016)
  The REST remodeling complex protects genomic integrity during embryonic neurogenesis
  Elife. 2016 Jan 8;5. pii: e09584. doi: 10.7554/eLife.09584.
• Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W (2016)
  CRISPR-Cas9 enables conditional mutagenesis of challenging loci.
  Sci Rep. 2016 Sep 1;6:32326. doi: 10.1038/srep32326.
• Vogt Weisenhorn DM, Giesert F, Wurst W (2016)
  Diversity matters – heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease
  Journal of Neurochemistry. 2016 May 21. DOI: 10.1111/jnc.13670. [Epub ahead of print]
• Weber T, Namikawa K, Winter B, Müller-Brown K, Kühn R, Wurst W, Köster RW (2016)
  Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
  Development. 2016 Oct 11. pii: dev.122721. [Epub ahead of print]
• Wurst W (2016)
  Animal models are valid to uncover disease mechanisms
  Public Library of Science Genetics. 2016 May 26. 12(5): e1006013. DOI: 10.1371/journal.pgen.1006013
• Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knöll B (2016)
  Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms
  Mol Neurobiol. 2016 Dec 2. [Epub ahead of print]

2015

• Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC (2015)
  Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders
  Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034.
• Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R (2015)
  Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
  Nat Biotechnol. 2015 Mar 24. doi: 10.1038/nbt.3198. [Epub ahead of print]
• Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, Prakash N (2015)
  Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse
  J Neurosci. 2015 Sep 30;35(39):13385-401. doi: 10.1523/JNEUROSCI.1722-15.2015.
• Garrett L, Zhang J, Zimprich A, Niedermeier KM, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Vogt Weisenhorn D, Wurst W, Hölter SM (2015)
  Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors
  Front Behav Neurosci. 2015 Nov 12;9:302.
• Hölter SM, Garrett L, Einicke J, Sperling B, Dirscherl P, Zimprich A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wurst W (2015)
  Assessing cognition in mice
  Curr Protoc Mouse Biol. 2015 Dec 2;5(4):331-58. doi: 10.1002/9780470942390.mo150068.
• Hölter SM, Einicke J, Sperling B, Zimprich A, Garrett L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wurst W (2015)
  Tests for anxiety-related behavior in mice
  Curr Protoc Mouse Biol. 2015 Dec 2;5(4):291-309. doi: 10.1002/9780470942390.mo150010.
• Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Angeli JP, Conrad M (2015)
  Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility
  J Biol Chem. 2015 Apr 28. pii: jbc.M115.656363. [Epub ahead of print]
• Rosen B, Schick J, Wurst W (2015)
  Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes
  Mamm Genome. 2015 Sep 4. [Epub ahead of print]
• Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W, Ortiz O (2015)
  Development of an intein-mediated split-Cas9 system for gene therapy
  Nucleic Acids Res. 2015 Jun 16. pii: gkv601. [Epub ahead of print]
• Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, Papaioannou VE (2015)
  Mga is essential for the survival of pluripotent cells during peri-implantation development
  Development. 2015 Jan 1;142(1):31-40. doi: 10.1242/dev.111104.
• Wefers B, Brandl C, Ortiz O, Wurst W, Kühn R (2015)
  Genome editing in mice using TALE nucleases
  Methods Mol Biol. 2016;1338:229-43. doi: 10.1007/978-1-4939-2932-0_17.
• Zhang J, Götz S, Vogt Weisenhorn DM, Simeone A, Wurst W, Prakash N (2015)
  A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/- mice
  Neurobiol Dis. 2015 Jun 3;82:32-45. doi: 10.1016/j.nbd.2015.05.015. [Epub ahead of print]

2014

• Brandl C, Ortiz O, Röttig B, Wefers B, Wurst W, Kühn R (2014)
  Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos
  FEBS Open Bio. 2014 Dec 3;5:26-35. doi: 10.1016/j.fob.2014.11.009. eCollection 2015
• Dykes IM, Lammerts van Bueren K, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ (2014)
  HIC2 is a Novel Dosage-Dependent Regulator of Cardiac Development Located Within the Distal 22q11 Deletion Syndrome Region
  Circ Res. 2014 Apr 18. [Epub ahead of print]
• Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J (2014)
  Uncoupling malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation
  Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13.
• Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D, Wurst W, Cazalla D, Stein V, Deussing JM, Refojo D (2014)
  MicroRNA-9 controls dendritic development by targeting REST
  Elife. 2014 Nov 18;3. doi: 10.7554/eLife.02755.
• Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M, Beckers J, Wurst W, Klingenspor M, Restrepo D; German Mouse Clinic Consortium, Sikela JM, de Angelis MH (2014)
  Generation of Mice Lacking DUF1220 Protein Domains: Effects on Fecundity and Hyperactivity
  Mamm Genome. 2014 Oct 12. [Epub ahead of print]
• Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Hölter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Neff F, Ollert M, Stoeger T, Yildrim AÖ, Eickelberg O, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Lufkin T, Stanton LW (2014)
  Pleiotropic functions for transcription factor zscan10
  PLoS One. 2014 Aug 11;9(8):e104568. doi: 10.1371/journal.pone.0104568. eCollection 2014
• Matthes M, Preusse M, Zhang J, Schechter J, Mayer D, Lentes B, Theis F, Prakash N, Wurst W, Trümbach D (2014)
  Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain
  Database (Oxford). 2014 Aug 20;2014. pii: bau083. doi: 10.1093/database/bau083. Print 2014.
• Meier F, Giesert F, Delic S, Faus-Kessler T, Matheus F, Simeone A, Hölter SM, Kühn R, Weisenhorn DM, Wurst W, Prakash N (2014)
  FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum
  PLoS One. 2014 Jul 1;9(7):e101124. doi: 10.1371/journal.pone.0101124. eCollection 2014.
• Pertek A, Meier F, Irmler M, Beckers J, Skylaki S, Endele M, Wurst W, Prakash N, Kühn R (2014)
  Simple Derivation of Transgene-Free iPS Cells by a Dual Recombinase Approach
  Mol Biotechnol. 2014 Mar 28. [Epub ahead of print]
• Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M (2014)
  The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice
  J Nutr Biochem. 2014 Oct 2. pii: S0955-2863(14)00197-1. doi: 10.1016/j.jnutbio.2014.09.002. [Epub ahead of print]
• Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J (2014)
  Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon
  Genome Res. 2014 Mar 18. [Epub ahead of print]
• Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia TV (2014)
  Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival
  Biol Open. 2014 Jul 25. pii: BIO20149399. doi: 10.1242/bio.20149399. [Epub ahead of print]
• Wefers B, Ortiz O, Wurst W, Kühn R (2014)
  Generation of targeted mouse mutants by embryo microinjection of TALENs
  Methods. 2014 Jan 10. pii: S1046-2023(14)00003-6. doi: 10.1016/j.ymeth.2014.01.002. [Epub ahead of print]
• Zimprich A, Garrett L, Deussing JM, Wotjak CT, Fuchs H, Gailus-Durner V, de Angelis MH, Wurst W, Hölter SM (2014)
  A robust and reliable non-invasive test for stress responsivity in mice
  Front Behav Neurosci. 2014 Apr 15;8:125. doi: 10.3389/fnbeh.2014.00125. eCollection 2014
• Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA (2014)
  Abnormal brain iron metabolism in irp2 deficient mice is associated with mild neurological and behavioral impairments
  PLoS One. 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014

2013

• Mueller-Rischart A-K, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Truembach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF (2013)
  The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
  Molecular cell doi:10.1016/j.molcel.2013.01.036
• Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013)
  Highly Efficient Targeted Mutagenesis in Mice Using TALENs
  Genetics. 2013 Aug 26. [Epub ahead of print]