Munich Cluster for Systems Neurology

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Curriculum vitae Prof. Dr. Wolfgang Wurst


    • 1975-1983 University of Freiburg, studies in Biology and Chemistry04/ 1983 Degree in Biology and Chemistry
    • 1983-1988 Ph.D. fellow at the Max-Planck-Institute of Immunobiology, Freiburg and at the Department of Immunogenetics, University Goettingen, (Ph.D. grade: summa cum laude)

Academic positions & appointments

    • 1994-1997 Research Group Leader at the Department of Mammalian Genetics, GSF-National ResearchCenter for Environment and Health, Munich/Neuherberg, Germany
    • 1997-2002 Group Leader (Associate Professor level) of Research Group ‘Molecular Neurogenetics’ at the Max-Planck-Institute of Psychiatry, Munich, and at the GSF-National Research Center for Environment and Health, Munich/Neuherberg
    • Since May 2002 Professor of Developmental Genetics, Dept. of Life Sciences, TechnicalUniversityMunich, and Director of the Institute of Developmental Genetics, GSF-NationalResearchCenter for Environment and Health (now, HelmholtzZentrum München, Munich/Neuherberg) and Head of Research Group ‘Molecular Neurogenetics’ at the Max- Planck-Institute of Psychiatry, Munich, Germany
    • Group Leader (provisional) of the Core Facility „Transgic Unit“ and „Behavioural Analysis of Mouse Models” of the Center for Neurodegenerative Diseases (DZNE), Site Munich, Germany

Research coordination

    • Coordinator of German Gene Trap Consortium (GGTC)
    • Coordinator of European Conditional Mouse Mutagenesis Program (EUCOMM;)
    • Coordinator of the Helmholtz Alliance for Mental Health and Ageing (HelMA))
    • Coordinator of the “Disease Genes to Pathways” network (DiGtoP); funded by BMBF NGFN-plus
    • Director of the Virtual Institute of Neurodegeneration

Membership in Editorial Boards

    • Editorial Board of Anatomy & Embryology
    • Editor of Special Edition Drug Discovery Today

Awards & honors

    • 1984-1988 DFG Student fellowship
    • 1988 DFG Travel Award
    • 1989 DAAD Postdoctoral Fellowship
    • 1989-1991 DFG Postdoctoral Fellowship

10 key papers

    • Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, et al. (2014) Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. J. Biol. Chem. 289, 10769–10784. doi: 10.1074/jbc.M113.515940
    • Wefers B, Panda SK, Ortiz O, Brandl C, Hensler S, Hansen J, Wurst W, Kühn R (2013) Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat. Protocols 8 (12), 2355-2379
    • Meyer M, Ortiz O, Hrabé de Angelis, M, Wurst W, Kühn R (2012) Modeling disease mutations by gene targeting in one-cell mouse embryos. PNAS 109 (24) 9354-9359.
    • Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer Ch, Vogl A M, Dedic N, Schumacher M, von Wolff G, Avrabos Ch, Touma Ch, Engblom D, Schütz G, Nave K-A, Eder M, Wotjak C T., Sillaber I, Holsboer F, Wurst W, Deussing JM (2011) Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1. Science 30: 333 (6051), 1903-1907
    • Collins FS, Rossant J, Wurst W (2007) A mouse for all reasons.Cell 128(1): 9-13.
    • Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133(1): 89-98.
    • Muller MB, Zimmermann S, Sillaber I,  Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kuhn R, Reul JM, Holsboer F, Wurst W (2003) Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6(10): 1100-7.
    • Wiles MV, Vauti F, Otte J, Fuchtbauer EM, Ruiz P, Fuchtbauer A, Arnold HH, Lehrach H, Metz T, von Melchner H, Wurst W (2000) Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.Nat Genet 24(1): 13-4.
    • Broccoli V, Boncinelli E, Wurst W (1999)The caudal limit of Otx2 expression positions the isthmic organizer. Nature 401(6749): 164-8.
    • Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W (1998) Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19(2): 162-6.

Responsible for content: Prof. Dr. Wolfgang Wurst