Munich Cluster for Systems Neurology

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Curriculum vitae Dr. Regina Feederle


    • 1990-1995 Studies of Biology at the Ludwig-Maximilians University, Munich
    • 1995-1996 Diploma thesis (MSc) at the Institute of Microbiology, Ludwig-Maximilians University, Munich

    • 1997-1999 Graduate studies (PhD) at the Institute of Clinical Molecular Biology and Tumor Genetics, GSF, Munich
    • 1999-2000 Postdoctoral fellow at the Institute of Clinical Molecular Biology and Tumor Biology, GSF, Munich
    • 2000-2004 Postdoctoral fellow at the University of Birmingham, Division of Cancer Studies, UK

Academic positions & appointments

    • 2004-2014 Senior scientist at the DKFZ-German Cancer Research Center, Division Pathogenesis of Virus Associated Tumors, Heidelberg
    • 2014-2015 Senior scientist at the Helmholtz Zentrum München, Monoclonal Antibody Facility, Munich
    • since 12/2015 Head of Monoclonal Antibody Core Facility and Research Group, Helmholtz Zentrum, Munich

10 key papers

    • Shumilov A, Tsai MH, Schlosser YT, Kratz AS, Bernhardt K, Fink S, Mizani T, Lin X, Jauch A, Mautner J, Kopp-Schneider A, Feederle R, Hoffmann I, Delecluse HJ. Epstein-Barr virus particles induce centrosome amplification and chromosoaml instability. Nat Commun. 2017, 8:14257
    • Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF. Seizure protein 6 and ist homolog seuzure 6-like protein are physiological substrates of BACE1 in neurons. Mol Neurodegener. 2016, 11(1):67.
    • Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Mol Med, 2016, 8(9):992-1004
    • Yu X, Ilecka M, Bartlett EJ, Schneidt V, Bhat R, Mautner J*, Feederle R*, Delecluse HJ*. Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells. Blood. 2015 125:601-610. doi: 10.1182
    • Tsai MH, Raykova A, Klinke O, Bernhardt K, Gärtner K, Leung CS, Geletneky K, Sertel S, Münz C, Feederle R*, Delecluse HJ*. Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. Cell Rep. 2013, doi:10.1016.
    • Feederle R, Linnstaedt SD, Bannert H, Lips H, Bencun M, Cullen BR, Delecluse HJ. A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus. PLoS Pathog. 2011, 7:e1001294
    • Busse C, Feederle R, Schnölzer M, Behrends U, Mautner J, Delecluse HJ. Epstein-Barr viruses which express a CD21 antibody provide evidence that gp350's functions extend beyond B cell surface binding. J Virol. 2010, 84:1139-47
    • Hutzinger R*, Feederle R*, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ, Hüttenhofer A. Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome. PLoS Pathog. 2009, 5(8):e1000547.
    • Feederle R, Kost M, Baumann M, Janz A, Drouet E, Hammerschmidt W, Delecluse HJ. The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBO J. 2000, 19: 3080-89
    • Baumann M*, Feederle R*, Kremmer E, Hammerschmidt W. Cellular proteins recruit viral replication proteins to activate the lytic origin of Epstein-Barr virus, oriLyt. EMBO J. 1999, 18: 6095-6105.

      *Indicates equal author contribution

Responsible for content: Dr. Regina Feederle