Publications Brendel

2023

• Ballweg A, Klaus C, Vogler L, Katzdobler S, Wind K, Zatcepin A, Ziegler SI, Secgin B, Eckenweber F, Bohr B, Bernhardt A, Fietzek U, Rauchmann BS, Stoecklein S, Quach S, Beyer L, Scheifele M, Simmet M, Joseph E, Lindner S, Berg I, Koglin N, Mueller A, Stephens AW, Bartenstein P, Tonn JC, Albert NL, Kümpfel T, Kerschensteiner M, Perneczky R, Levin J, Paeger L, Herms J, Brendel M (2023)
  [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.
  J Neuroinflammation. 2023 Mar 11;20(1):68. doi: 10.1186/s12974-023-02749-2. PMID: 36906584; PMCID: PMC10007845.
• Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI) (2023)
  sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease.
  EMBO Mol Med. 2023 Jan 9:e16987. doi: 10.15252/emmm.202216987. Epub ahead of print. PMID: 36620941.
• Delker A, Schleske M, Liubchenko G, Berg I, Zacherl MJ, Brendel M, Gildehaus FJ, Rumiantcev M, Resch S, Hürkamp K, Wenter V, Unterrainer LM, Bartenstein P, Ziegler SI, Beyer L, Böning G (2023)
  Biodistribution and dosimetry for combined [177Lu]Lu-PSMA-I&T/[225Ac]Ac-PSMA-I&T therapy using multi-isotope quantitative SPECT imaging.
  Eur J Nucl Med Mol Imaging. 2023 Jan 11. doi: 10.1007/s00259-022-06092-1. Epub ahead of print. PMID: 36629878.
• Gnörich J, Reifschneider A, Wind K, Zatcepin A, Kunte ST, Beumers P, Bartos LM, Wiedemann T, Grosch M, Xiang X, Fard MK, Ruch F, Werner G, Koehler M, Slemann L, Hummel S, Briel N, Blume T, Shi Y, Biechele G, Beyer L, Eckenweber F, Scheifele M, Bartenstein P, Albert NL, Herms J, Tahirovic S, Haass C, Capell A, Ziegler S, Brendel M (2023)
  Depletion and activation of microglia impact metabolic connectivity of the mouse brain.
  Neuroinflammation. 2023 Feb 24;20(1):47. doi: 10.1186/s12974-023-02735-8. PMID: 36829182; PMCID: PMC9951492.
• Koeglsperger T, Rumpf SL, Schließer P, Struebing FL, Brendel M, Levin J, Trenkwalder C, Höglinger GU, Herms J (2023)
  Neuropathology of incidental Lewy body & prodromal Parkinson's disease.
  Mol Neurodegener. 2023 May 12;18(1):32. doi: 10.1186/s13024-023-00622-7. PMID: 37173733; PMCID: PMC10182593.
• Palleis C, Forbrig R, Lehner L, Quach S, Albert NL, Brendel M, Schöberl F, Straube A (2023)
  Lyme neuroborreliosis: An unusual case with extensive (peri)vasculitis of the middle cerebral artery.
  Eur J Neurol. 2023 Jan 13. doi: 10.1111/ene.15633. Epub ahead of print. PMID: 36636924.
• Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T (2023)
  Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal.
  Neuroimage Clin. 2023 Apr 11;38:103402. doi: 10.1016/j.nicl.2023.103402. Epub ahead of print. PMID: 37087820.
• van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM (2023)
  A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
  Nat Neurosci. 2023 Jan 12. doi: 10.1038/s41593-022-01240-0. Epub ahead of print. PMID: 36635496.
• Zatcepin A, Kopczak A, Holzgreve A, Hein S, Schindler A, Duering M, Kaiser L, Lindner S, Schidlowski M, Bartenstein P, Albert N, Brendel M, Ziegler Sl (2023)
  Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients.
  Z Med Phys. 2023 Jan 20:S0939-3889(22)00128-3. doi: 10.1016/j.zemedi.2022.11.008. Epub ahead of print. PMID: 36682921.
• Zounek AJ, Albert NL, Holzgreve A, Unterrainer M, Brosch-Lenz J, Lindner S, Bollenbacher A, Boening G, Rupprecht R, Brendel M, von Baumgarten L, Tonn JC, Bartenstein P, Ziegler S, Kaiser L (2023)
  Feasibility of radiomic feature harmonization for pooling of [18F]FET or [18F]GE-180 PET images of gliomas.
  Z Med Phys. 2023 Jan 27:S0939-3889(22)00138-6. doi: 10.1016/j.zemedi.2022.12.005. Epub ahead of print. PMID: 36710156.

2022

• Antons M, Lindner M, Grosch M, Oos R, Palumbo G, Brendel M, Ziegler S, Bartenstein P, Dieterich M, Zwergal A (2022)
  Longitudinal [18]UCB-H/[18F]FDG imaging depicts complex patterns of structural and functional neuroplasticity following bilateral vestibular loss in the rat.
  Sci Rep. 2022 Apr 11;12(1):6049. doi: 10.1038/s41598-022-09936-w. PMID: 35411002; PMCID: PMC9001652.
• Bartos LM, Kunte ST, Beumers P, Xiang X, Wind K, Ziegler S, Bartenstein P, Choi H, Lee DS, Haass C, von Baumgarten L, Tahirovic S, Albert NL, Lindner S, Brendel M (2022)
  Single cell radiotracer allocation via immunomagentic sorting (scRadiotracing) to disentangle PET signals at cellular resolution
  J Nucl Med. 2022 May 19:jnumed.122.264171. doi: 10.2967/jnumed.122.264171. Epub ahead of print. PMID: 35589403.
• Bartos LM, Kirchleitner SV, Blobner J, Wind K, Kunze LH, Holzgreve A, Gold L, Zatcepin A, Kolabas ZI, Ulukaya S, Weidner L, Quach S, Messerer D, Bartenstein P, Tonn JC, Riemenschneider MJ, Ziegler S, von Baumgarten L, Albert NL, Brendel M (2022)
  18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model.
  Front Med (Lausanne). 2022 Oct 17;9:992993. doi: 10.3389/fmed.2022.992993. PMID: 36325388; PMCID: PMC9621314.
• Biel D, Luan Y, Brendel M, Hager P, Dewenter A, Moscoso A, Otero Svaldi D, Higgins IA, Pontecorvo M, Römer S, Steward A, Rubinski A, Zheng L, Schöll M, Shcherbinin S, Ewers M, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative (2022)
  Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease.
  Alzheimers Res Ther. 2022 Nov 7;14(1):166. doi: 10.1186/s13195-022-01105-5. PMID: 36345046; PMCID: PMC9639286.
• Blume T, Deussing M, Biechele G, Peters F, Zott B, Schmidt C, Franzmeier N, Wind K, Eckenweber F, Sacher C, Shi Y, Ochs K, Kleinberger G, Xiang X, Focke C, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Adelsberger H, Rominger A, Cumming P, Willem M, Dorostkar MM, Herms J, Brendel M (2022)
  Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
  Front Aging Neurosci. 2022 Mar 30;14:854031. doi: 10.3389/fnagi.2022.854031. PMID: 35431893; PMCID: PMC9007038.
• Blume T, Filser S, Sgobio C, Peters F, Neumann U, Shimshek D, Saito T, Saido TC, Brendel M, Herms J (2022)
  β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice.
  Front Aging Neurosci. 2022 Jul 22;14:909586. doi: 10.3389/fnagi.2022.909586. PMID: 35936777; PMCID: PMC9354544.
• Finze A, Wahl H, Janowitz D, Buerger K, Linn J, Rominger A, Stöcklein S, Bartenstein P, Wollenweber FA, Catak C, Brendel M (2022)
  Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy.
  Front Aging Neurosci. 2022 Feb 3;13:786143. doi: 10.3389/fnagi.2021.786143. PMID: 35185518; PMCID: PMC8851392.
• Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M (2022)
  Tau deposition patterns are associated with functional connectivity in primary tauopathies.
  Nat Commun. 2022 Mar 15;13(1):1362. doi: 10.1038/s41467-022-28896-3. PMID: 35292638; PMCID: PMC8924216
• Frontzkowski L, Ewers M, Brendel M, Biel D, Ossenkoppele R, Hager P, Steward A, Dewenter A, Römer S, Rubinski A, Buerger K, Janowitz D, Binette AP, Smith R, Strandberg O, Carlgren NM, Dichgans M, Hansson O, Franzmeier N (2022)
  Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading.
  Nat Commun. 2022 Aug 20;13(1):4899. doi: 10.1038/s41467-022-32592-7. PMID: 35987901; PMCID: PMC9392750.
• Katzdobler S, Nitschmann A, Barthel H, Bischof G, Beyer L, Marek K, Song M, Wagemann O, Palleis C, Weidinger E, Nack A, Fietzek U, Kurz C, Strupp M,Häckert J, Stapf T, Ferschmann C, Scheifele M, Eckenweber F, Biechele G, Franzmeier N, Dewenter A, Schönecker S, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Stephens AW, van Eimeren T, Neumaier B, Drzezga A, Danek A, Classen J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Levin J, Brendel M; German Imaging Initiative for Tauopathies (GII4T) (2022)
  Additive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome.
  Eur J Nucl Med Mol Imaging. 2022 Sep 14. doi: 10.1007/s00259-022-05964-w. Epub ahead of print. PMID: 36102964.
• Künze G, Kümpfel R, Rullmann M, Barthel H, Brendel M, Patt M, Sabri O (2022)
  Molecular Simulations Reveal Distinct Energetic and Kinetic Binding Properties of [18F]PI-2620 on Tau Filaments from 3R/4R and 4R Tauopathies.
  ACS Chem Neurosci. 2022 Jun 28. doi: 10.1021/acschemneuro.2c00291. Epub ahead of print. PMID: 35762647.
• Messerschmidt K, Barthel H, Brendel M, Scherlach C, Hoffmann KT, Rauchmann BS, Rullmann M, Marek K, Villemagne VL, Rumpf JJ, Saur D, Schroeter ML, Schildan A, Patt M, Beyer L, Song M, Palleis C, Katzdobler S, Fietzek UM, Scherlach C, Hoffmann KT, Rauchmann BS, Rullmann M, Marek K, Villemagne VL, Rumpf JJ, Saur D, Schroeter ML, Schildan A, Patt M, Beyer L, Song M, Palleis C, Katzdobler S, Fietzek UM, Herms J, Boetzel K, Bartenstein P, Levin J, Seibyl JP, Höglinger G, Classen J, Sabri O (2022)
  18F-PI-2620 Tau PET Improves the Imaging Diagnosis of Progressive Supranuclear Palsy.
  J Nucl Med. 2022 Apr 14:jnumed.121.262854. doi: 10.2967/jnumed.121.262854. Epub ahead of print. PMID: 35422444.
• Rauchmann BS, Brendel M. Franzmeier N, Trappmann L, Ewers M, Palleis C, Weidinger E, Biechele G, Schuster S, Finze A, Eckenweber F, Rupprecht R, Rominger A, Goldhardt O, Grimmer T, Keeser D, Stoecklein S, Dietrich O, Bartenstein P. Levin J. Höglinger G, Perneczky R (2022)
  Microglial Activation and Connectivity in Alzheimer Disease and Aging.
  Ann Neurol. 2022 Aug 1. doi: 10.1002/ana.26465. Epub ahead of print. PMID: 36053756.
• Rullmann M, Brendel M, Schroeter ML, Saur D, Levin J, Perneczky RG, Tiepolt S, Patt M, Mueller A, Villemagne VL, Classen J, Stephens AW, Sabri O, Barthel H, On Behalf Of The German Imaging Initiative For Tauopathies Gii T (2022)
  Multicenter 18F-PI-2620 PET for In Vivo Braak Staging of Tau Pathology in Alzheimer's Disease.
  Biomolecules. 2022 Mar 16;12(3):458. doi: 10.3390/biom12030458. PMID: 35327650; PMCID: PMC8946049.
• Schuster S, Beyer L, Palleis C, Harris S, Schmitt J, Weidinger E, Prix C, Bötzel K, Danek A, Rauchmann BS, Stöcklein S, Lindner S, Unterrainer M, Albert NL, Mittlmeier LM, Wetzel C, Rupprecht R, Rominger A, Bartenstein P, Perneczky R, Levin J, Höglinger GU, Brendel M, Dekorsy FJ (2022)
  Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome.
  Brain Sci. 2022 Jan 31;12(2):204. doi: 10.3390/brainsci12020204. PMID: 35203967; PMCID: PMC8870519.
• Shi Y, Cui M, Ochs K, Brendel M, Strübing FL, Briel N, Eckenweber F, Zou C, Banati RB, Liu GJ, Middleton RJ, Rupprecht R, Rudolph U, Zeilhofer HU, Rammes G, Herms J, Dorostkar MM (2022)
  Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).
  Nat Neurosci. 2022 Mar;25(3):317-329. doi: 10.1038/s41593-022-01013-9. Epub 2022 Feb 28. PMID: 35228700.
• Steward A, Biel D, Brendel M, Dewenter A, Roemer S, Rubinski A, Luan Y, Dichgans M, Ewers M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI) (2022)
  Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease.
  Alzheimers Dement. 2022 Nov 25. doi: 10.1002/alz.12867. Epub ahead of print. PMID: 36433865.
• Unterrainer M, Mahler C, Schumacher AM, Ruf V, Blum B, Quach S, Brendel M, Rupprecht R, Bartenstein P, Kerschensteiner M, Kümpfel T, Albert NL (2022)
  Amino Acid Uptake, Glucose Metabolism, and Neuroinflammation in John Cunningham Virus Associated Progressive Multifocal Leukoencephalopathy.
  Clin Nucl Med. 2022 Feb 21. doi: 10.1097/RLU.0000000000004093. Epub ahead of print. PMID: 35195584.
• Völter F, Beyer L, Eckenweber F, Scheifele M, Bui N, Patt M, Barthel H, Katzdobler S, Palleis C, Franzmeier N, Levin J, Perneczky R, Rauchmann BS, Sabri O, Hong J, Cumming P, Rominger A, Shi K, Bartenstein P, Brendel M (2022)
  Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings.
  Eur J Nucl Med Mol Imaging. 2022 Dec 27. doi: 10.1007/s00259-022-06087-y. Epub ahead of print. PMID: 36572740.
• von Rohr K, Unterrainer M, Holzgreve A, Kirchner MA, Li Z, Unterrainer LM, Suchorska B, Brendel M, Tonn JC, Bartenstein P, Ziegler S, Albert NL, Kaiser L (2022)
  Can Radiomics Provide Additional Information in [18F]FET-Negative Gliomas?
  Cancers (Basel). 2022 Oct 5;14(19):4860. doi: 10.3390/cancers14194860. PMID: 36230783.
• Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE (2022)
  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
  Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. PMID: 35690868; PMCID: PMC9188195.
• Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M (2022)
  Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases".
  Sci Transl Med. 2022 Aug 24;14(659):eabn5104. doi: 10.1126/scitranslmed.abn5104. Epub 2022 Aug 24. PMID: 36001676.
• Zatcepin A, Heindl S, Schillinger U, Kaiser L, Lindner S, Bartenstein P, Kopczak A, Liesz A, Brendel M, Ziegler SI (2022)
  Reduced Acquisition Time [18F]GE-180 PET Scanning Protocol Replaces Gold-Standard Dynamic Acquisition in a Mouse Ischemic Stroke Model.
  Front Med (Lausanne). 2022 Feb 10;9:830020. doi: 10.3389/fmed.2022.830020. PMID: 35223925; PMCID: PMC8866959.