Munich Cluster for Systems Neurology

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Curriculum vitae Prof. Dr. Rüdiger Klein


    • 1977-1979 Studies in Biology in Marburg/Lahn, Germany
    • 1979/1980 Exchange student at JuniataCollege, Huntingdon, PA, USA
    • 1980-1985 Graduate Studies in Biology in Tübingen, Germany
    • 1987 Ph.D. (magna cum laude)
    • 1989-1990 Postdoctoral fellow at the National Cancer Institute - Frederick Cancer Research and Development Center, Frederick, MD, USA. After Dec. 1988 at the Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
    • 1991 - 1993 Staff Scientist at the Bristol-Myers Squibb Pharmaceutical Research Institute

Academic positions & appointments

    • 1993 - 2001 Group Leader at the European Molecular Biology Laboratory, Heidelberg, Germany
    • Since 2001 Director and Scientific Member at the Max-Planck-Institute of Neurobiology, Martinsried, and Head of Department of Molecular Neurobiology
    • Since 2002 Member of the Faculty of Biology of the Ludwig-Maximilian-University of München
    • Since 2006 Honorary Professor, Faculty of Biology, Ludwig-Maximilian-University of München

Membership in Editorial Boards

    • 2002 - 2007 Member of Editorial Board, Genes & Development
    • 2002 - 2009 Associate Editor, Molecular and Cellular Neuroscience
    • Since 2003 Member of Editorial Board, Current Opinion in Neurobiology
    • 2007 Section Editor, Signalling Mechanisms, Current Opinion in Neurobiology
    • Since 2009 Member of the EMBO long-term postdoctoral fellowship committee
    • Since 2010 Editorial Committee of the Annual Review of Cell and Developmental Biology

Awards & honors

    • 1979/80 Fulbright fellowship for undergraduate studies in the USA
    • 1988-90 Postdoctoral fellowship from the BoehringerIngelheimFonds
    • 1998 Elected member of the European Molecular Biology Organization (EMBO)
    • 2005 Family-Hansen-Prize
    • 2008 Remedios Caro Almela Prize for Research in Developmental Neurobiology

10 key papers

    • Aron L, Klein P, Pham TT, Kramer ER, Wurst W, Klein R (2010). Pro-survival role forParkinson’s associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol 8(4): e1000349.
    • Filosa A, Paixão S, Honsek SD, Carmona MA, Becker L, Feddersen B, Gaitanos L, Rudhard Y, Schoepfer R, Klopstock T, Kullander K, Rose CR, Pasquale EB, Klein R# (2009). Neuron-glia communication via EphA4/ephrinA3 modulates LTP through glial glutamate transport. NatNeurosci12(10):1285-92.
    • Kramer ER, Aron L, Ramakers GMJ, Seitz S, Zhuang X, Beyer K, Smidt MP, Klein R (2007). Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLOS Biol, 5(3): e39
    • Kramer ER, Knott L, Su F, Dessaud E, Krull CE, Helmbacher F, Klein R (2006).Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.Neuron 50, 35-47.
    • Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R (2005). Regulation of EphA4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron 47, 515-528.
    • Grunwald IC, Korte M, Adelmann G, Plueck A, Kullander K, Adams R, Frotscher M, Bonhoeffer T, Klein R (2004).Hippocampal plasticity requires postsynaptic ephrinBs. NatNeurosci 7, 33-40.
    • Zimmer M, Palmer A, Köhler J, Klein R (2003). EphB/ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Bioly 5(10):869-878.
    • Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R (2002). EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell 9, 725-737.
    • Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R (2001). The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104, 57-69.
    • Brückner K, Pasquale EB, Klein R (1997). Tyrosine phosphorylation of transmembrane ligands for Eph receptors.Science 275, 1640-1642.

Responsible for content: Prof. Dr. Rüdiger Klein