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Remodelers tap into nucleosome plasticity

Nat Struct Mol Biol. 2017 Apr 6;24(4):341-343. doi: 10.1038/nsmb.3394.

Authors/Editors: Singh HR, Murawska M, Ladurner AG.
Publication Date: 2017

2017_04_singh

Abstract

Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H chromatin remodeler distorts the histone octamer structure upon binding to the nucleosome, then taps into this induced plasticity to productively achieve nucleosome sliding.

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