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Press Release: Stem cells in the brain: limited self-renewal

Stem cells in the brain can produce neurons and are consequently seen as a hope for treatment. A team of researchers including SyNergy-PI Magdalena Götz from the Helmholtz Zentrum München and Ludwig-Maximilians-Universität München (LMU) has now discovered that the self-renewal rate of the stem cells is however limited, explaining why their number drops over the course of a lifetime.

09.03.2015

Stammzellen_götz
Image: A subclone of transiently amplifying
progenitors in the subependymal zone.

Source: J.Michel, ISF/Helmholtz Zentrum München

Stem cells in the brain: limited self-renewal
Until now it was thought that maintaining the stem cell pool was based on the self-renewal of individual stem cells. The team of scientists headed by Dr. Jovica Ninkovic and SyNergy-PI Dr. Magdalena Götz were able to refute this: Both the self-renewal rate and the diversity of neurons formed from the stem cells are limited, and the number of stem cells decreases with age. Press release Helmholtz Zentrum

Stammzellen im Gehirn sind kein ewiger Jungbrunnen
Bisher ging man davon aus, dass die Erhaltung des Stammzell-Pools auf der Selbsterneuerung einzelner Stammzellen beruht. Das Wissenschaftlerteam um Dr. Filippo Calzolari, Dr. Jovica Ninkovic und SyNergy-PI Dr. Magdalena Götz konnte dies nun widerlegen: sowohl die Selbsterneuerungsrate, als auch die Diversität der gebildeten Nervenzellen aus den Stammzellen sind begrenzt, die Anzahl der Stammzellen nimmt mit der Lebensdauer ab.

Presse Meldung Helmholtz Zentrum

Presse Meldung LMU