Munich Cluster for Systems Neurology
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Curriculum vitae Prof. Dr. Dr. h.c. Christian Haass

  • Date of Birth: December 19, 1960

Training

  • 1981 - 1985 Studies of Biology at Ruprechts-Karls-University, Heidelberg

  • 1989 Ph.D. (summa cum laude)

  • 1990 - 1992 Post-doctoral Fellow at the Harvard Medical School

Academic positions & appointments

  • 1993 - 1995 Assistant Professor of Neurology at Harvard Medical School

  • 1995 - 1999 Professor (C3) of Molecular Biology at the Central Institute of Mental Health, Mannheim

  • since 1999 Professor of Biochemistry (C4) and Head of the Department of Metabolic Biochemistry at the Biomedical Center (LMU, Munich)

  • since 2009 Coordinator of the German Center for Neurodegenerative Disorders (DZNE) in Munich

Research coordination

  • 2000 - 2006 Coordinator of the DFG- Priority Program “Cellular Mechanisms of Alzheimer's Disease”

  • since 2000 Speaker of the Sonderforschungsbereich 596 (Collaborative Research Center) “Molecular Mechanisms of Neurodegeneration”

  • 2006 - 2011 Member and sub-project speaker of the DFG Excellence Cluster "Center for Integrated Protein Science Munich"

  • since 2012 Speaker of the Munich Cluster of Systems Neurology

Membership in Editorial Boards

  • 2000 - 2005 Member of the Editorial Board of J. Biol. Chem.

  • 2005 - 2010 Advisory Board Member of EMBO Reports

  • since 2005 Advisory Board Member of the EMBO J.

  • since 2005 Member of the Board of Reviewers of Science

  • since 2008 Advisory Board Member of EMBO Mol. Medicine

  • since 2012 Advisory Board Member of J. Neuroscience

Awards & honors

  • 1986 Award of the Heidelberg Society for Molecular Biology for the Diploma thesis

  • 1990 - 1991 Stipend from the Boehringer Ingelheim Fonds (Post-doctoral Fellowship)

  • 1990 Award of the Heidelberg Society for Molecular Biology for the best Ph.D. thesis

  • 1991 - 1992 Stipend from the Deutsche Forschungsgemeinschaft (Post-doctoral Fellowship)

  • 1996 Organon Research Award

  • 1997 Award of the Heidelberg Academy of Sciences / Award of the German Hirnliga e.V.

  • 2000 International Alois Alzheimer Award

  • 2002 Gottfried Wilhelm Leibniz Award of the DFG / Family Hansen Award
    Ernst Jung Award for Medicine / Potamkin Award of the AAN

  • 2003 Elected EMBO member / Member, Leopoldina

  • 2006 MetLife Foundation Promising Award for Medical Research
    Sheik Hamdan Award for Medical Sciences (in the category Biology of Aging)

  • 2010 Honorary Doctorate of the University of Zurich

  • 2013 ERC Advanced Grant

  • 2015 MetLife Foundation Award for Medical Research

  • 2016 Rolf Becker Award
    Elected Member of the Bavarian Academy of Sciences and Humanities

  • 2017 AFTD Biomarkers Award

10 key papers

  • Suárez-Calvet M, Caballero MA, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C, for the Dominantly Inherited Alzheimer Network. Early changes of CSF sTREM2 in Dominantly Inherited Alzheimer’s Disease follow markers of Amyloid Deposition and Neuronal Injury. Science Translational Medicine (in press) (2016)
  • Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Muller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C. eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526:443-7 (2015)
  • Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleo A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sanchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science translational medicine 6:243ra286 (2014)
  • Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314:664-6 (2006)
  • Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nat Cell Biol 5:486-8 (2003)
  • Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol 2:848-51 (2000)
  • Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat Cell Biol 2:205-11 (2000)
  • Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer’s disease by beta-secretase cleavage within the secretory pathway. Nat Med 1:1291-6 (1995)
  • Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359:322-5 (1992)
  • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357:500-3 (1992)

Responsible for content: Prof. Dr. Dr. h.c. Christian Haass