Munich Cluster for Systems Neurology

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Our infrastructure and expertise

Current infrastructural initiatives

  • Systems Biology
  • Control of Regulatory Networks (CoReNe) / H.-W. Mewes,  W. Wurst
  • European Conditional Mouse Mutagenesis Program
  • (EUCOMM) / W. Wurst
  • German Mouse Clinic / W. Wurst
  • Helmholtz Association for Mental Health in an Aging Society (HelMA) / W. Wurst
  • Systems Biology of Metabotypes (SysMBO) / T. Meitinger, H.-W. Mewes
  • Pathomechanisms and Systems Neuroscience
  • Bernstein Center for Computational Neuroscience München (BCCN) / A. Herz
  • ForNeuroCell II / J. Winkler, M. Götz
  • Graduate School for Systemic Neurosciences (GSNLMU) / B. Grothe
  • Munich Center for Neurosciences (MCNLMU) / B. Grothe
  • Research Training Group 1373: Brain Signaling: from Neurons to Circuits / A. Konnerth
  • SFB 571 Autoimmune Reactions: From Manifestations and Mechanisms to Therapy / R. Hohlfeld
  • SFB 596 Molecular Mechanisms of Neurodegeneration / C. Haass
  • SFB 870 Assembly and Function of Neuronal Circuits in Sensory Processing / B. Grothe
  • Clinical Neurology and Translation
  • Competence Network Multiple Sclerosis - Control-MS Consortium / B. Hemmer
  • German Center for Neurodegenerative Diseases München (DZNE) / C. Haass
  • Institute of Clinical Neuroimmunology (INIM) / R. Hohlfeld
  • Institute for Stroke and Dementia Research (ISD) / M. Dichgans
  • German Center for Vertigo and Balance Disorders-IFB / K. Jahn, M. Dieterich, S. Glasauer
  • m4 Munich Biotech Cluster for Personalized Medicine / H. Domdey, P. Bartenstein

Coordinated by LMU Munich, the SyNergy cluster is a collaborative initiative of LMU and TUM, joined in their commitment to strengthen neuroscience and clinical translation. Our initiative is based on the outstanding expertise and infrastructure in pathomechanistic neurological research at the two universities, and the numerous non-university institutions in Munich, as well as many current initiatives (see box to right). This expertise is flanked by strong research efforts in systems neuroscience, which will allow us to address the higher-level functional disturbances and plasticity (e.g., sensory or cognitive) involved in neurological disease. This neuroscience expertise is mirrored by a focus on systems biology both within the universities, as well as at the Max Planck Institutes and the Helmholtz Center Munich (HMGU). As a result of these initiatives, a superb infrastructure for establishing systems neurology research already exists. This infrastructure will serve as a basis for the SyNergy cluster, and is complemented by a dense network of institutions dedicated to translational neurological research in neurodegeneration (DZNE), neuroinflammation (INIM) and vascular dysfunction (ISD). Thus, new research findings can seamlessly be integrated into existing efforts aimed at clinical translation – aided by collaboration with the recently established industry partnership alliance, the BMBF-funded "Munich Biotech Cluster m4 for personalized medicine". Major ongoing building initiatives, namely the construction of the Biomedical Center (BMC) and the DZNE/ISD building (shared by LMU and TUM research groups) at the "HighTech Campus Großhadern", will further strengthen the environment for basic, translational and clinical neuroscience research (Figure 3). These new buildings will provide dedicated lab space modules for Clinician-Scientist Groups and will house the new SyNergy professors. These construction projects and the subsequent relocation of existing research groups will result in a unique clustering of SyNergy scientists. The strong support by both Munich Excellence Universities and the State of Bavaria ensures the quick launch and long-term sustainability of our measures.